Publikationen

Publikationen 2025

Nägler F, Vorbach S, Mohamed AA, Thaqi S, Adebahr S, Ehret F, …, Gawish A et al. Pulmonary Stereotactic Body Radiotherapy of Oligometastatic Head-and-Neck Squamous Cell Carcinoma - A multicenter retrospective study. Int J Radiat Oncol Biol Phys. 2025; dx.doi.org/10.1016/j.ijrobp.2024.12.015

Witt M, Weber U, Adeberg S, Baumann K-S, Zink K. Proton and carbon ion beam spot size measurement using 5 different detector types. Int J Part Ther. 2025;15(100638):100638. linkinghub.elsevier.com/retrieve/pii/S2331518024007042.

Publikationen 2024

Abouegylah M, Udugamasooriya SS, Ahmed AA, Tas KT, Lishewski P, Smalec E, Schmich G,.Vorwerk H, Eberle F, Adeberg S, Gawish A, Ismail AA. The role of oral nutritional supplements in head and neck cancer patients undergoing chemoradiotherapy. Healthcare (Basel). 2024;12(20). dx.doi.org/10.3390/healthcare12202070

Alissa M, Zink K, Röser A, Flatten V, Schoenfeld AA, Czarnecki D. Monte Carlo calculated beam quality correction factors for high energy electron beams. Phys Med. 2024 Jan 117(103179):103179. doi:10.1016/j.ejmp.2023.103179. PMID: 38042061.

Baumann K-S, Lourenço A, Wulff J, Vilches-Freixas G, Palmans H. Investigating the impact of the effective point of measurement for plane-parallel ionization chambers in clinical proton beams. Phys Med Biol. 2024;70(1). dx.doi.org/10.1088/1361-6560/ad9e7c

Blum I, Wong JS, Godino Padre K, Stolzenberg J, Fuchs H, Baumann K-S, Poppe B, Looe HK. Fano cavity test and investigation of the response of the Roos chamber irradiated by proton beams in perpendicular magnetic fields up to 1 T. Phys Med Biol. 2024 Apr 69(8):085021. doi:10.1088/1361-6560/ad311a. PMID: 38452383.

Brunner TB, Boda-Heggemann J, Bürgy D, Corradini S, Dieckmann UK, Gawish A, et al. Dose prescription for stereotactic body radiotherapy: general and organ-specific consensus statement from the DEGRO/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery. Strahlenther Onkol. 2024;200(9):737–50. dx.doi.org/10.1007/s00066-024-02254-2

Derksen L, Adeberg S, Zink K, Baumann K-S. Comparison of two methods simulating inter-track interactions using the radiobiological Monte Carlo toolkit TOPAS-nBio. Phys Med Biol. 2024 Jan 69(3):03NT01. doi:10.1088/1361-6560/ad1cf4. PMID: 38198700.

Ehret F, Zühlke O, Leonille Schweizer, Kahn J, Csapo-Schmidt C, Roohani S, …, Adeberg S et al. Validation of a methylation-based signature for subventricular zone involvement in glioblastoma. J Neurooncol. 2024;167(1):89–97. dx.doi.org/10.1007/s11060-024-04570-0

Elsayad K, Guenova E, Assaf C, Nicolay JP, Trautinger F, Stadler R, …, Adeberg S et al. Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group. Eur J Cancer. 2024;212:115064. dx.doi.org/10.1016/j.ejca.2024.115064

Elsayad K, Guenova E, Fournier B, Fernandes C, Clementel E, Papadavid E, et al. Real-world pattern-of-care analysis of primary cutaneous lymphomas radiation therapy among European Organisation for Research and treatment of Cancer members. Int J Radiat Oncol Biol Phys. 2024; dx.doi.org/10.1016/j.ijrobp.2024.11.011

Elsayad K, Stadler R, Eich HT. Pegylated interferon combined with low-dose total skin electron beam therapy for advanced stage mycosis fungoides: Two case reports and literature review. Adv Radiat Oncol. 2024;10(1):101663. dx.doi.org/10.1016/j.adro.2024.101663

El Shafie RA, Bernhardt D, Welzel T, Schiele A, Schmitt D, Thalmann P (imbi), …, Adeberg S et al. Stereotactic Radiosurgery for 1-10 brain metastases to avoid whole-brain radiotherapy - results of the CYBER-SPACE randomized phase 2 trial. Neuro Oncol. 2024; dx.doi.org/10.1093/neuonc/noae201

Failing T, Hensley FW, Keil B, Zink K. Investigations on the beam quality correction factor for ionization chambers in high-energy brachytherapy dosimetry. Phys Med Biol. 2024;69(16). dx.doi.org/10.1088/1361-6560/ad638b

Flatten V, Devendranath H-A, Kroh J, Witt M, Baumann K-S, Gall K, et al. Evaluation of a prototype array for daily quality assurance in spot scanning proton therapy. J Appl Clin Med Phys. 2024;25(11):e14454. dx.doi.org/10.1002/acm2.14454

Gebauer B, Baumann K-S, Fuchs H, Georg D, Oborn BM, Looe H-K, Lühr A. Proton dosimetry in a magnetic field: Measurement and calculation of magnetic field correction factors for a plane‐parallel ionization chamber. Med Phys. 2024 Mar 51(3):2293–2305. doi:10.1002/mp.16797. PMID: 37898105.

Hänze J, Mengen LM, Mernberger M, Tiwari DK, Plagge T, Nist A, …, Subtil FSB, Theiss U, Eberle F, …, Engenhart-Cabillic R et al. Transcriptomic response of prostate cancer cells to carbon ion and photon irradiation with focus on androgen receptor and TP53 signaling. Radiat Oncol. 2024;19(1):85. dx.doi.org/10.1186/s13014-024-02480-z

Janke F, Stritzke F, Dvornikovich K, Franke H, Angeles AK, Riediger AL, …, Adeberg S et al. Early circulating tumor DNA changes predict outcomes in head and neck cancer patients under re-radiotherapy. Int J Cancer. 2024;156(4):853–64. dx.doi.org/10.1002/ijc.35152

Lang K, Held T, Freudlsperger C, Plath K, Hoffmann J, Plinkert PK, …, Adeberg S. Oral cavity squamous cell carcinoma: Impact of clear margin distance on locoregional control in patients undergoing postoperative radiotherapy. Technol Cancer Res Treat. 2024; 23:15330338241258596. dx.doi.org/10.1177/15330338241258596

Rickel JK, Zeeb D, Knake S, Urban H, Konczalla J, Weber KJ, Zeiner PS, Pagenstecher A, Hattingen E, Kemmling A, Fokas E, Adeberg S, u.a. Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review. Neurol Res Pract. 2024 Apr 6(1). doi:10.1186/s42466-024-00314-7. PMID: 38570823.

Simeonov Y, Weber U, Krieger M, Schuy C, Folkerts M, Paquet G, …, Zink K. A fast 3D range-modulator delivery approach: Validation of the FLUKA model on a Varian ProBeam system including a robustness analysis. Cancers (Basel). 2024;16(20). dx.doi.org/10.3390/cancers16203498

Walter A, Hoegen-Saßmannshausen P, Stanic G, Rodrigues JP, Adeberg S, Jäkel O, Frank M, Giske K. Segmentation of 71 anatomical structures necessary for the evaluation of guideline-conforming clinical target volumes in head and neck cancers. Cancers (Basel). 2024 Jan 16(2):415. doi:10.3390/cancers16020415. PMID: 38254904.

Weusthof K, Held T, Lang K, Rachel ZE, Harrabi SB, Plath K, Freudlsperger C, Herfarth K, Debus J, Haberer T, Münter M, Jensen, AD, Adeberg, S. Combined photon and carbon ion radiation therapy for sinonasal malignancies: Results of the HIT–SNT prospective phase 2 trial. Int J Radiat Oncol Biol Phys. 2024 Apr 118(5):1563–1574. doi:10.1016/j.ijrobp.2023.09.037. PMID: 37866761.

Weykamp F, Schaub L, Eichhorn M, Winter H, Schirmacher P, Thomas M, …, Adeberg S et al. Carbon ion beam radiation therapy as part of a trimodal therapy for non-small cell superior sulcus tumors: The INKA study. Adv Radiat Oncol. 2024;9(9):101573. dx.doi.org/10.1016/j.adro.2024.101573

Witt M, Weber U, Flatten V, Stolzenberg J, Engenhart-Cabillic R, Zink K, Baumann KS. On the way to accounting for lung modulation effects in particle therapy of lung cancer patients-A review. Cancers (Basel). 2024;16(21). dx.doi.org/10.3390/cancers16213598

Wulff J, Paul A, Bäcker CM, Baumann K-S, Esser JN, Koska B, Timmermann B, Verbeek NG, Bäumer C. Consistency of Faraday cup and ionization chamber dosimetry of proton fields and the role of nuclear interactions. Med Phys. 2024 Mar 51(3):2277–2292. doi:10.1002/mp.16819. PMID: 37991110.

Yawson AK, Walter A, Wolf N, Klüter S, Hoegen P, Adeberg S, Debus J, Frank M, Jäkel O, Giske K. Essential parameters needed for a U-Net-based segmentation of individual bones on planning CT images in the head and neck region using limited datasets for radiotherapy application. Phys Med Biol. 2024 Jan 69(3):035008. doi:10.1088/1361-6560/ad1996. PMID: 38164988.

Zhang T, Stengl C, Derksen L, Palskis K, Koritsidis K, Zink K, Adeberg S, …, Theiss U, …, Baumann KS et al. Analysis of hydrogen peroxide production in pure water: Ultrahigh versus conventional dose-rate irradiation and mechanistic insights. Med Phys. 2024;51(10):7439–52. dx.doi.org/10.1002/mp.17335

Zink K, Baumann KS, Theiss U, Subtil F, Lahrmann S, Eberle F, Adeberg S. Organization and operation of multi particle therapy facilities: the Marburg Ion-Beam Therapy Center, Germany (MIT). Health Technol (Berl). 2024 Mai. doi:10.1007/s12553-024-00881-4.

Publikationen 2023

Abouegylah M, Elemary O, Ahmed AA, ElFeky AM, Fayed H, Gawish M, …, Gawish A. Impact of breath hold on regional nodal irradiation and heart volume in field in left breast cancer adjuvant irradiation. Clin Transl Oncol. 2023;26(1):288–96. dx.doi.org/10.1007/s12094-023-03256-9

Ahern V, Adeberg S, Fossati P, Garrett R, Hoppe B, Mahajan A, Orlandi E, Orecchia R, Prokopovich D, Seuntjens J, u. a. An international approach to estimating the indications and number of eligible patients for carbon ion radiation therapy (CIRT) in Australia. Radiother Oncol. 2023 Oct 187(109816):109816. doi:10.1016/j.radonc.2023.109816. PMID: 37480996

Alissa M, Zink K, Czarnecki D. Investigation of Monte Carlo simulations of the electron transport in external magnetic fields using Fano cavity test. Z Med Phys. 2023 Nov 33(4):499–510. doi:10.1016/j.zemedi.2022.07.002. PMID: 36030166.

Alissa M, Zink K, Kapsch R-P, Schoenfeld AA, Frick S, Czarnecki D. Experimental and Monte Carlo‐based determination of magnetic field correction factors kB,Qk_B,Q in high‐energy photon fields for two ionization chambers. Med Phys. 2023 Jul 50(7):4578–4589. doi:10.1002/mp.16345. PMID: 36897832

Baumann K-S, Derksen L, Witt M, Adeberg S, Zink K. The influence of different versions of FLUKA and GEANT4 on the calculation of response functions of ionization chambers in clinical proton beams. Phys Med Biol. 2023 Dec 68(24):24NT01. doi:10.1088/1361-6560/ad0ad4. PMID: 37939402.

Baumann K-S, Gomà C, Wulff J, Kretschmer J, Zink K. Monte Carlo calculated ionization chamber correction factors in clinical proton beams – deriving uncertainties from published data. Phys Med. 2023 Sep 113(102655):102655. doi:10.1016/j.ejmp.2023.102655. PMID: 37603909

Burg JM, Flatten V, Wulff J, Timmermann B, Vorwerk H, Zink K. Induced luminescence in water and PMMA - spectral analysis for irradiations with proton beams within the clinical energy range. Biomed Phys Eng Express. 2023 Jul 9(5):057001. doi:10.1088/2057-1976/ace6a2. PMID: 37437552.

Charuchinda W, Horst F, Simeonov Y, Schuy C, Penchev P, Poulsen P, Sitarz M, Busold S, Reidel C-A, Folkerts M, …, Zink K, u. a. 3D range-modulators for proton therapy: near field simulations with FLUKA and comparison with film measurements. J Phys Conf Ser. 2023 Jun 2431(1):012081. doi:10.1088/1742-6596/2431/1/012081.

Czarnecki D, Zink K, Alissa M, Flatten V, Espelage T, Schoenfeld AA. Validation of an EGSnrc‐based Monte Carlo model for a complex 2D‐array for technical QA measurements of a linear accelerator. Med Phys. 2023 Apr 50(4):2552–2559. doi:10.1002/mp.16205. PMID: 36604950.

Derksen L, Flatten V, Engenhart-Cabillic R, Zink K, Baumann K-S. A method to implement inter-track interactions in Monte Carlo simulations with TOPAS-nBio and their influence on simulated radical yields following water radiolysis. Phys Med Biol. 2023 Jun 68(13):135017. doi:10.1088/1361-6560/acdc7d. PMID: 37285861.

Fink CA, Weykamp F, Adeberg S, Bozorgmehr F, Christopoulos P, Lang K, König L, Hörner-Rieber J, Thomas M, Steins M, u. a. Comorbidity in limited disease small-cell lung cancer: Age-adjusted Charlson comorbidity index and its association with overall survival following chemoradiotherapy. Clin Transl Radiat Oncol. 2023 Jul 42(100665):100665. doi:10.1016/j.ctro.2023.100665. PMID: 37564923.

Gkika E, Kostyszyn D, Fechter T, Moustakis C, Ernst F, Boda-Heggemann J, Sarria G, Dieckmann K, Dobiasch S, Duma MN, Eberle F, Kroeger K, Häussler B, Izaguirre V, Jazmati D, Lautenschläger S, u. a. Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities. Strahlenther Onkol. 2023 Nov 199(11):973–981. doi:10.1007/s00066-023-02085-7. PMID: 37268767.

Lautenschlaeger S, Dumke C, Exeli L, Hauswald H, Engenhart-Cabillic R, Eberle F. Treatment of primary or recurrent non-resectable pancreatic cancer with proton beam irradiation combined with gemcitabine-based chemotherapy. Strahlenther Onkol. 2023 Nov 199(11):982–991. doi:10.1007/s00066-023-02106-5. PMID: 37428207.

Köksal M, Özkan O, Holderried T, Heine A, Brossart P, Gawish A, et al. Optimized conformal total body irradiation with VMAT using a linear-accelerator-based radiosurgery treatment system in comparison to the golden standard Helical TomoTherapy. Cancers (Basel). 2023;15(17). dx.doi.org/10.3390/cancers15174220

Oertel M, Hering D, Nacke N, Kittel C, Kröger K, Kriz J, Fuchs M, Baues C, Vordermark D, Engenhart-Cabillic R, u. a. Radiation therapy in the German Hodgkin study group HD 16 and HD 17 trials: Quality assurance and dosimetric analysis for Hodgkin lymphoma in the modern era. Adv Radiat Oncol. 2023 May-Jun 8(3):101169. doi:10.1016/j.adro.2022.101169. PMID: 36896214.

Oertel M, Hering D, Baues C, Kittel C, Fuchs M, Kriz J, Kröger K, Vordermark D, Herfarth K, Engenhart-Cabillic R, u. a. Radiation doses to mediastinal organs at risk in early-stage unfavorable Hodgkin lymphoma– a risk stratified analysis of the GHSG HD17 trial. Front Oncol. 2023 May 13. doi:10.3389/fonc.2023.1183906. PMID: 37213291.

Roers J, Czarnecki D, Alissa M, Zink K. Spectral analysis of Monte Carlo calculated fluence correction and cema conversion factors for high-energy photon beams at different depths. Front Phys. 2023 Jan 10. doi:10.3389/fphy.2022.1075514. dx.doi.org/10.3389/fphy.2022.1075514.

Rossi G, Failing T, Gainey M, Kollefrath M, Hensley F, Zink K, Baltas D. Determination of the dose rate around a HDR 192Ir brachytherapy source with the microDiamond and the microSilicon detector. Z Med Phys. 2023 Nov 33(4):463–478. doi:10.1016/j.zemedi.2022.07.004. PMID: 36038432.

Wächter S, Roth S, Gercke N, Schötz U, Dikomey E, Engenhart-Cabillic R, Maurer E, Bartsch D, Di Fazio P. Anti-proliferative effect of radiotherapy and implication of immunotherapy in anaplastic thyroid cancer cells. Life (Basel). 2023 Jun 13(6):1397. doi:10.3390/life13061397. PMID: 37374179.

Publikationen 2022

Alissa M, Zink K, Tessier F, Schoenfeld AA, Czarnecki D. Monte Carlo calculated beam quality correction factors for two cylindrical ionization chambers in photon beams. Phys Med. 2022 Feb 94:17–23. doi:10.1016/j.ejmp.2021.12.012. PMID: 34972070.

Baack L, Schuy C, Brons S, Horst F, Voss B, Zink K, Haberer T, Durante M, Weber U. Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams. Phys Med. Dec 2022 104:136–144. doi:10.1016/j.ejmp.2022.10.029. PMID: 36403543.

Bitzer M, Voesch S, Albert J, Bartenstein P, Bechstein W, Blödt S, Brunner T, Dombrowski F, Evert M, Follmann M, …, Vorwerk H, u.a. 2022a. S3-Leitlinie: Diagnostik und Therapie biliärer Karzinome: Kurzversion 2.00 - Juni 2021, AWMF-Registernummer: 032-053OL. Z Gastroenterol. 2022a Feb 60(02):219–238. doi:10.1055/a-1589-7638. PMID: 35042249

Bitzer M, Voesch S, Albert J, Bartenstein P, Bechstein W, Blödt S, Brunner T, Dombrowski F, Evert M, Follmann M, …, Vorwerk H, u. a. S3-Leitlinie – Diagnostik und Therapie biliärer Karzinome: Langversion 2.0 - Juni 2021 - AWMF-Registernummer: 032-053OL. Z Gastroenterol. 2022b Feb 60(02):e186–e227. doi:10.1055/a-1589-7854. PMID: 35148560.

Dapper H, Belka C, Bock F, Budach V, Budach W, Christiansen H, Debus J, Distel L, Dunst J, Eckert F, …, Engenhart-Cabillic R, …, Vorwerk H, u. a. Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations: An overview and recommendations of the consortium academic radiation oncology of the German Society for Radiation Oncology (DEGRO). Strahlenther Onkol. 2022 Jan 198(1):1–11. doi:10.1007/s00066-021-01861-7. PMID: 34786605.

Dumke R, Dumke C, Eberle F, Nimsky C, Keber U, Engenhart-Cabillic R, Lautenschläger S. Monocentric evaluation of Ki-67 labeling index in combination with a modified RPA score as a prognostic factor for survival in IDH-wildtype glioblastoma patients treated with radiochemotherapy. Strahlenther Onkol. 2022 Oct 198(10):892–906. doi:10.1007/s00066-022-01959-6. PMID: 35612598.

Eberle F, Engenhart-Cabillic R, Schymalla MM, Dumke C, Schötz U, Subtil FSB, Baumann K-S, Stuck BA, Langer C, Jensen AD, Hauswald H, Lautenschläger S. Carbon ion beam boost irradiation in malignant tumors of the nasal vestibule and the anterior nasal cavity as an organ-preserving therapy. Front Oncol. 2022 Feb 12. doi:10.3389/fonc.2022.814082. PMID: 35242709.

Failing T, Hartmann GH, Hensley FW, Keil B, Zink K. Enhancement of the EGSnrc code egs_chamber for fast fluence calculations of charged particles. Z Med Phys. Nov 2022 32(4):417–427. doi:10.1016/j.zemedi.2022.04.003. PMID: 35643800.

Foote RL, Tsujii H, Imai R, Tsuji H, Hug EB, Kanai T, Lu JJ, Debus J, Engenhart-Cabillic R, Mahajan A. The majority of United States citizens with cancer do not have access to carbon ion radiotherapy. Front Oncol. 2022 Jul 12. doi:10.3389/fonc.2022.954747. PMID: 35875126.

Lautenschlaeger FS, Dumke R, Schymalla M, Hauswald H, Carl B, Stein M, Keber U, Jensen A, Engenhart-Cabillic R, Eberle F. Comparison of carbon ion and photon reirradiation for recurrent glioblastoma. Strahlenther Onkol. 2022 May 198(5):427–435. doi:10.1007/s00066-021-01844-8. PMID: 34523017.

Rogers S, Baumert B, Blanck O, Böhmer D, Boström J, Engenhart-Cabillic R, Ermis E, Exner S, Guckenberger M, Habermehl D, u. a. Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO). Strahlenther Onkol. 2022 Oct 198(10):919–925. doi:10.1007/s00066-022-01991-6. PMID: 36006436.

Schade S, Engenhart-Cabillic R, Zink K, Czarnecki D. The fast calibration model for dosimetry with an electronic portal imaging device. J Appl Clin Med Phys. Nov 2022 23(11). doi:10.1002/acm2.13599. PMID: 35876832.

Simeonov Y, Weber U, Schuy C, Engenhart-Cabillic R, Penchev P, Flatten V, Zink K. Development, Monte Carlo simulations and experimental evaluation of a 3D range-modulator for a complex target in scanned proton therapy. Biomed Phys Eng Express. 2022 Mar 8(3):035006. doi:10.1088/2057-1976/ac5937. PMID: 35226887.

Subtil FSB, Gröbner C, Recknagel N, Parplys AC, Kohl S, Arenz A, Eberle F, Dikomey E, Engenhart-Cabillic R, Schötz U. Dual PI3K/mTOR inhibitor NVP-BEZ235 leads to a synergistic enhancement of cisplatin and radiation in both HPV-negative and -positive HNSCC cell lines. Cancers (Basel). 2022 Jun 14(13):3160. doi:10.3390/cancers14133160. PMID: 35804930.

Tambas M, van der Laan HP, Steenbakkers RJHM, Doyen J, Timmermann B, Orlandi E, Hoyer M, Haustermans K, Georg P, Burnet NG, …, Eberle F, u. a. 2022. Current practice in proton therapy delivery in adult cancer patients across Europe. Radiother Oncol. 2022 Feb 167:7–13. doi:10.1016/j.radonc.2021.12.004. PMID: 34902370.

Tiwari DK, Hannen R, Unger K, Kohl S, Heß J, Lauber K, Subtil FSB, Dikomey E, Engenhart-Cabillic R, Schötz U. IL1 pathway in HPV-negative HNSCC cells is an indicator of radioresistance after photon and carbon ion irradiation without functional involvement. Front Oncol. 2022 Apr 12. doi:10.3389/fonc.2022.878675. PMID: 35530351.

Vorwerk H, Engenhart-Cabillic R. Students’ learning behavior in digital education for radiation oncology. Strahlenther Onkol. 2022 Jan 198(1):12–24. doi:10.1007/s00066-021-01858-2. PMID: 34842943.

Publikationen 2021

Baumann K-S, Derksen L, Witt M, Michael Burg J, Engenhart-Cabillic R, Zink K. Monte Carlo calculation of beam quality correction factors in proton beams using FLUKA. Phys Med Biol. 2021 Aug 66(17):17NT01. doi:10.1088/1361-6560/ac1c4b. PMID: 34378546.

Baumann K-S, Kaupa S, Bach C, Engenhart-Cabillic R, Zink K. Monte Carlo calculation of perturbation correction factors for air-filled ionization chambers in clinical proton beams using TOPAS/GEANT. Z Med Phys. 2021 May 31(2):175–191. doi:10.1016/j.zemedi.2020.08.004. PMID: 33775521.

Burg JM, Flatten V, Witt M, Derksen L, Weber U, Engenhart-Cabillic R, Vorwerk H, Experimental determination of modulation power of lung tissue for particle therapy. Phys Med Biol. 2021 Dec 66(24):245018. doi:10.1088/1361-6560/ac3e0d. PMID: 34844221.

Derksen L, Pfuhl T, Engenhart-Cabillic R, Zink K, Baumann K-S. Investigating the feasibility of TOPAS-nBio for Monte Carlo track structure simulations by adapting GEANT4-DNA examples application. Phys Med Biol. 2021 Aug 66(17):175023. doi:10.1088/1361-6560/ac1d21. PMID: 34384060.

König L, Jäkel C, von Knebel Doeberitz N, Kieser M, Eberle F, Münter M, Debus J, Herfarth K. Glioblastoma radiotherapy using Intensity modulated Radiotherapy (IMRT) or proton Radiotherapy—GRIPS Trial (Glioblastoma Radiotherapy via IMRT or Proton BeamS): a study protocol for a multicenter, prospective, open-label, randomized, two-arm, phase III study. Radiat Oncol. 2021 Dec 16(1). doi:10.1186/s13014-021-01962-8. PMID: 34930368.

Flatten V, Burg J, Witt M, Derksen L, Fragoso Costa P, Wulff J, Bäumer C, Timmermann B, Weber U, Vorwerk H, Engenhart-Cabillic R, Zink K, Baumann K-S. Estimating the modulating effect of lung tissue in particle therapy using a clinical CT voxel histogram analysis. Phys Med Biol. 2021 Sep 66(18):185002. doi:10.1088/1361-6560/ac176e. PMID: 34298533.

Hartmann GH, Andreo P, Kapsch R-P, Zink K. Cema‐based formalism for the determination of absorbed dose for high‐energy photon beams. Med Phys. 2021 Nov 48(11):7461–7475. doi:10.1002/mp.15266. PMID: 34613620.

Lo AC, Dieckmann K, Pelz T, Gallop-Evans E, Engenhart-Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, u. a. Pediatric classical Hodgkin lymphoma. Pediatr Blood Cancer. 2021 May 68(S2). doi:10.1002/pbc.28562. PMID: 33818890.

Paz AES, Baumann K-S, Weber UA, Witt M, Zink K, Durante M, Graeff C. Compensating for beam modulation due to microscopic lung heterogeneities in carbon ion therapy treatment planning. Med Phys. 2021 Dec 48(12):8052–8061. doi:10.1002/mp.15292. PMID: 34668589.

Schäfer N, Bumes E, Eberle F, Fox V, Gessler F, Giordano FA, Konczalla J, Onken J, Ottenhausen M, Scherer M, u. a. Implementation, relevance, and virtual adaptation of neuro-oncological tumor boards during the COVID-19 pandemic: a nationwide provider survey. J Neurooncol. 2021 Jul 153(3):479–485. doi:10.1007/s11060-021-03784-w. PMID: 34115248.

Simeonov Y, Weber U, Schuy C, Engenhart-Cabillic R, Penchev P, Durante M, Zink K. Monte Carlo simulations and dose measurements of 2D range-modulators for scanned particle therapy. Z Med Phys. 2021 May 31(2):203–214. doi:10.1016/j.zemedi.2020.06.008. PMID: 32711939.

Publikationen 2020

Andreo P, Burns DT, Kapsch RP, McEwen M, Vatnitsky S, Andersen CE, Ballester F, Borbinha J, Delaunay F, Francescon P, Hanlon MD, Mirzakhanian L, Muir B, Ojala J, Oliver CP, Pimpinella M, Pinto M, de Prez LA, Seuntjens J, Sommier L, Teles P, Tikkanen J, Vijande J, Zink K. Determination of consensus k _Q values for megavoltage photon beams for the update of IAEA TRS-398. Phys Med Biol. 2020 May 7;65(9):095011. doi: 10.1088/1361-6560/ab807b. PMID: 32182598.

Baumann KS, Kaupa S, Bach C, Engenhart-Cabillic R, Zink K. Monte Carlo calculation of beam quality correction factors in proton beams using TOPAS/GEANT4. Phys Med Biol. 2020 Mar 6;65(5):055015. doi: 10.1088/1361-6560/ab6e53. PMID: 31962306.

Baumann KS, Flatten V, Weber U, Lautenschläger S, Eberle F, Zink K, Engenhart-Cabillic R. Correction to: Effects of the Bragg peak degradation due to lung tissue in proton therapy of lung cancer patients. Radiat Oncol. 2020 Feb 3;15(1):29. doi: 10.1186/s13014-020-1475-x. Erratum for: Radiat Oncol. 2019 Oct 25;14(1):183. PMID: 32014028; PMCID: PMC6996163.

Burg JM, Horst F, Wulff J, Timmermann B, Vorwerk H, Zink K. Optical range determination of clinical proton beams in water. A comparison with standard measurement methods. Phys Med. 2020 May;73:197-203. doi: 10.1016/j.ejmp.2020.03.012. Epub 2020 May 4. PMID: 32380438.

Degenhardt S, Dreffke K, Schötz U, Petersen C, Engenhart-Cabillic R, Rothkamm K, Dahm-Daphi J, Dikomey E, Mansour WY. Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells. Front Oncol. 2020 Aug 20;10:1480. doi: 10.3389/fonc.2020.01480. PMID: 32974177; PMCID: PMC7468517.

Eberle F, Lautenschläger S, Engenhart-Cabillic R, Jensen AD, Carl B, Stein M, Debus J, Hauswald H. Carbon Ion Beam Reirradiation in Recurrent High-Grade Glioma. Cancer Manag Res. 2020 Jan 28;12:633-639. doi: 10.2147/CMAR.S217824. PMID: 32095084; PMCID: PMC6995286.

Flatten V, Friedrich A, Engenhart-Cabillic R, Zink K. A phantom based evaluation of the dose prediction and effects in treatment plans, when calculating on a direct density CT reconstruction. J Appl Clin Med Phys. 2020 Mar;21(3):52-61. doi: 10.1002/acm2.12824. PMID: 32176455; PMCID: PMC7075385.

Guckenberger M, Baus WW, Blanck O, Combs SE, Debus J, Engenhart-Cabillic R, Gauer T, Grosu AL, Schmitt D, Tanadini-Lang S, Moustakis C. Definition and quality requirements for stereotactic radiotherapy: consensus statement from the DEGRO/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery. Strahlenther Onkol. 2020 May;196(5):417-420. doi: 10.1007/s00066-020-01603-1. PMID: 32211940; PMCID: PMC7182610.

Hartmann GH, Hensley F, Kapsch RP, Poppe B, Sauer O, Würfel J, Zink K. Ermittlung der Wasser-Energiedosis nach der Sondenmethode gemäß DIN 6800 Teil 1: Vorschlag für eine Erweiterung der Grundgleichung [Detector Based Determination of Water Absorbed Dose According to DIN 6800 Teil 1: Suggestion for an Extension of the Fundamental Formalism]. Z Med Phys. 2020 Feb;30(1):24-39. German. doi: 10.1016/j.zemedi.2019.05.001. Epub 2019 Oct 2. PMID: 31585786.

Klement RJ, Sonke JJ, Allgäuer M, Andratschke N, Appold S, Belderbos J, Belka C, Dieckmann K, Eich HT, Flentje M, Grills I, Eble M, Hope A, Grosu AL, Semrau S, Sweeney RA, Hörner-Rieber J, Werner-Wasik M, Engenhart-Cabillic R, Ye H, Guckenberger M. Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy. Radiother Oncol. 2020 Jan;142:210-216. doi: 10.1016/j.radonc.2019.07.008. Epub 2019 Aug 17. PMID: 31431371.

Klement RJ, Sonke JJ, Allgäuer M, Andratschke N, Appold S, Belderbos J, Belka C, Blanck O, Dieckmann K, Eich HT, Mantel F, Eble M, Hope A, Grosu AL, Nevinny-Stickel M, Semrau S, Sweeney RA, Hörner-Rieber J, Werner-Wasik M, Engenhart-Cabillic R, Ye H, Grills I, Guckenberger M. Correlating Dose Variables with Local Tumor Control in Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer: A Modeling Study on 1500 Individual Treatments. Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):579-586. doi: 10.1016/j.ijrobp.2020.03.005. Epub 2020 Mar 15. PMID: 32188579.

Lerch S, Berthold S, Ziemann F, Dreffke K, Subtil FSB, Senger Y, Jensen A, Engenhart-Cabillic R, Dikomey E, Wittig A, Eberle F, Schötz U. HPV-positive HNSCC cell lines show strongly enhanced radiosensitivity after photon but not after carbon ion irradiation. Radiother Oncol. 2020 Jul 24;151:134-140. doi:10.1016/j.radonc.2020.07.032. Epub ahead of print. PMID: 32717362.

Martin D, Balermpas P, Gollrad J, Weiß C, Valentini C, Stuschke M, Schäfer H, Henckenberens C, Debus J, Krug D, Kuhnt T, Brunner T, Bostel T, Engenhart-Cabillic R, Nestle U, Combs S, Belka C, Hautmann M, Hildebrandt G, Gani C, Polat B, Rödel C, Fokas E. RADIANCE - Radiochemotherapy with or without Durvalumab in the treatment of anal squamous cell carcinoma: A randomized multicenter phase II trial. Clin Transl Radiat Oncol. 2020 May 1;23:43-49. doi:10.1016/j.ctro.2020.04.010. PMID: 32420463; PMCID: PMC7218223.

Schötz U, Balzer V, Brandt FW, Ziemann F, Subtil FSB, Rieckmann T, Köcher S, Engenhart-Cabillic R, Dikomey E, Wittig A, Arenz A. Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining. Cancers (Basel). 2020 Feb 18;12(2):467. doi:10.3390/cancers12020467. PMID: 32085396; PMCID: PMC7072694.

Sieron HL, Eberle F, Gress TM, Mahnken AH, Wiegand S. Safety of Prophylactic Gastrostomy Tube Placement and Gastrostomy Tube Usage in Patients Treated by Radio(chemo)therapy for Head and Neck Cancer. Anticancer Res. 2020 Feb;40(2):1167-1173. doi:10.21873/anticanres.14059. PMID: 32014970.

Stein M, Dohmen H, Wölk B, Eberle F, Kolodziej M, Acker T, Uhl E, Jensen A. Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields. Front Oncol. 2020 Apr 21;10:477. doi:10.3389/fonc.2020.00477. PMID: 32373516; PMCID: PMC7186451.

Tikkanen J, Zink K, Pimpinella M, Teles P, Borbinha J, Ojala J, Siiskonen T, Gomà C, Pinto M. Calculated beam quality correction factors for ionization chambers in MV photon beams. Phys Med Biol. 2020 Mar 26;65(7):075003. doi:10.1088/1361-6560/ab7107. PMID: 31995531.

Publikationen 2019

Arenz A, Patze J, Kornmann E, Wilhelm J, Ziemann F, Wagner S, Wittig A, Schoetz U, Engenhart-Cabillic R, Dikomey E, Fritz B. HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. Head Neck. 2019 Nov;41(11):3869-3879. doi:10.1002/hed.25924. PMID: 31441163

Baumann KS, Flatten V, Weber U, Lautenschläger S, Eberle F, Zink K, Engenhart-Cabillic R. Correction to: Effects of the Bragg peak degradation due to lung tissue in proton therapy of lung cancer patients. Radiat Oncol. 2020 Feb 3;15(1):29. doi: 10.1186/s13014-020-1475-x. Erratum for: Radiat Oncol. 2019 Oct 25;14(1):183. PMID: 32014028.

Baumann K-S, Horst F, Zink K, Gomà C. Comparison of penh, fluka, and Geant4/topas for absorbed dose calculations in air cavities representing ionization chambers in high‐energy photon and proton beams. Med Phys. 2019 46(10):4639–4653. PMID: 31350915

Fels J, Pigorsch S, Vorwerk H, Engenhart-Cabillic R, van Oorschot B. Palliative care in everyday practice of radiation oncologists : Results from a web-based survey among medical members of the German Society for Radiation Oncology (DEGRO). Strahlenther Onkol. 2019 Jul;195(7):659-667. doi:10.1007/s00066-018-1403-2. PMID: 30498845

Flatten V, Baumann K-S, Weber U, Engenhart-Cabillic R, Zink K. Quantification of the dependencies of the Bragg peak degradation due to lung tissue in proton therapy on a CT-based lung tumor phantom. Phys Med Biol. 2019 64(15):155005. doi:10.1088/1361-6560/ab2611. PMID: 31151126.

Gani C, Gani N, Zschaeck S, Eberle F, Schaeffeler N, Hehr T, Berger B, Fischer SG, Claßen J, Zipfel S, Rödel C, Teufel M, Zips D. Organ Preservation in Rectal Cancer: The Patients' Perspective. Front Oncol. 2019 May 10;9:318. doi:10.3389/fonc.2019.00318. PMID: 31134146.

Gerum S, Jensen AD, Roeder F. Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review. World J Gastrointest Oncol. 2019 11(5):367–376. doi:10.4251/wjgo.v11.i5.367. PMID: 31139307.

Jensen AD, Debus J. Cost-effectiveness analysis (CEA) of IMRT plus C12 boost vs IMRT only in adenoid cystic carcinoma (ACC) of the head and neck. Radiat Oncol. 2019 Nov 6;14(1):194. doi:10.1186/s13014-019-1395-9. PMID: 31694720.

Hartmann GH, Zink K. A Monte Carlo study on the PTW 60019 microDiamond detector. Med Phys. 2019 46(11):5159–5172. doi:10.1002/mp.13721. PMID: 31314919

Howitz S, Wiezorek T, Wittig A, Vorwerk H, Zink K. Fluence-weighted average subfield size in helical TomoTherapy. Z Med Phys. 2019 29(4):337–348. doi:10.1016/j.zemedi.2019.03.003.

Lautenschlaeger S, Iancu G, Flatten V, Baumann K, Thiemer M, Dumke C, Zink K, Hauswald H, Vordermark D, Mauz-Körholz C, Engenhart-Cabillic R, Eberle F. Advantage of proton-radiotherapy for pediatric patients and adolescents with Hodgkin’s disease. Radiat Oncol. 2019 14(1). doi:10.1186/s13014-019-1360-7. PMID: 31477141.

Schröder C, Engenhart-Cabillic R, Kirschner S, Blank E, Buchali A. Changes of lung parenchyma density following high dose radiation therapy for thoracic carcinomas – an automated analysis of follow up CT scans. Radiat Oncol. 2019 14(1). doi:10.1186/s13014-019-1276-2. PMID: 31036015.

Seltzsam S, Ziemann F, Dreffke K, Preising S, Arenz A, Schötz U, Engenhart-Cabillic R, Dikomey E, Wittig A. In HPV-positive HNSCC cells, functional restoration of the p53/p21 pathway by proteasome inhibitor bortezomib does not affect radio- or chemosensitivity. Transl Oncol. 2019 12(3):417–425. doi:10.1016/j.tranon.2018.11.013. PMID: 30554133.

Publikationen 2018

Caldwell RB, Braselmann H, Heuer S, Schötz U, Zitzelsberger H. Gain‐of‐function analysis of cis‐acting diversification elements in DT40 cells. Immunol Cell Biol. 2018 96(9):948–957. doi:10.1111/imcb.12158. PMID: 29665088.

Daher T, Tur MK, Brobeil A, Etschmann B, Witte B, Engenhart-Cabillic R, Krombach G, Blau W, Grimminger F, Seeger W, Klussmann JP, Bräuninger A, Gattenlöhner. Combined human papillomavirus typing and TP53 mutation analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. Head Neck. 2018 40(6):1109-1119. doi:10.1002/hed.25041. PMID: 29522268.

Fasslrinner F, Schetelig J, Burchert A, Kramer M, Trenschel R, Hegenbart U, Stadler M, Schäfer-Eckart K, Bätzel M, Eich H,Stuschke M, Engenhart-Cabillic R, Krause M, Dreger P, Neubauer A, Ehninger G, Beelen D, Berdel WE, Siepmann T,Stelljes M, Bornhäuser M. Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: retrospective follow-up of an open-label, randomised phase 3 trial. Lancet Haematol 2018 5(4):e161-e169 1016/S2352-3026(18)30022-X. doi:10.1016/S2352-3026(18)30022-X. PMID: 29550384.

Gökyildirim MY, Grandel U, Hattar K, Dahlem G, Schuetz E, Leinberger FH, Eberle F, Sibelius U, Grimminger F, Seeger W, Engenhart-Cabillic R, Dikomey E, Subtil FSB. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines. Oncotarget 2018 9(48):28976-2898810.18632. doi:10.18632/oncotarget.25665. PMID: 29989005.

Linge A, Schötz U, Löck S, Lohaus F, von Neubeck C, Gudziol V, Nowak A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Lauber K, Pigorsch S, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Krause M, Belka C, Baumann M; DKTK-ROG. Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC. Radiother Oncol. 2018 127(1):27-35. doi:10.1016/j.radonc.2017.12.007. PMID: 29295747.

Krombach J, Hennel R, Brix N, Orth M, Schötz U, Ernst A, Schuster J, Zuchtriegel G, Reichel CA, Bierschenk S, Sperandio M, Vogl T, Unkel S, Belka C, Lauber K. Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells. Oncolmmunology. 2018
8(1):e1523097. doi:10.1080/2162402X. PMID: 30546963.

Hartmann GH, Zink K. Decomposition of the dose conversion factor based on fluence spectra of secondary charged particles: Application to lateral dose profiles in photon fields. Med Phys. 2018 45(9):4246–4256. doi:10.1002/mp.13081. PMID: 29974479.

Ringbæk TP, Weber U, Santiago A, Iancu G, Wittig A, Grzanka L, Bassler N, Engenhart-Cabillic R, Zink K. Validation of new 2D ripple filters in proton treatments of spherical geometries and non-small cell lung carcinoma cases. Phys Med Biol. 2018 63(24):245020. doi:10.1088/1361-6560/aaede9. PMID: 30523868.

Publikationen 2017

Baumann K-S, Witt M, Weber U, Engenhart-Cabillic R, Zink K. An efficient method to predict and include Bragg curve degradation due to lung-equivalent materials in Monte Carlo codes by applying a density modulation. Phys Med Biol. 2017 62(10):3997–4016. doi:10.1088/1361-6560/aa641f. PMID: 28252449.

Czarnecki D, Poppe B, Zink K. Monte Carlo-based investigations on the impact of removing the flattening filter on beam quality specifiers for photon beam dosimetry. Med Phys. 2017 44(6):2569–2580. doi:10.1002/mp.12252. PMID: 28369978

Eberle F, Leinberger FH, Saulich MF, Seeger W, Engenhart-Cabillic R, Hänze J, Hattar K, Dikomey E, Subtil FSB. In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed. Clin Transl Radiat Oncol. 2017 2:69–75. doi:10.1016/j.ctro.2017.02.001. PMID: 29658004.

Hattar K, Reinert CP, Sibelius U, Gökyildirim MY, Subtil FSB, Wilhelm J, Eul B, Dahlem G, Grimminger F, Seeger W, u. a. Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro. Cancer Immunol Immunother. 2017 66(6):799–809. doi:10.1007/s00262-017-1980-4. PMID: 28314957.

Hoch S, Thelen K, Vorwerk H, Netzer C, Wilhelm T, Günzel T, Teymoortash A. Impact of Different Treatment Concepts on Regional Failure in Advanced Oropharyngeal Cancer. Anticancer Res. 2017 Feb;37(2):727-734. doi:10.21873/anticanres.11370. PMID: 28179323.

Horst F, Schuy C, Weber U, Brinkmann K-T, Zink K. Measurement of charge- and mass-changing cross sections for He4+C12 collisions in the energy range 80–220 MeV/u for applications in ion beam therapy. Phys Rev C. 2017 96(2). doi:10.1103/physrevc.96.024624.

Horst F, Fehrenbacher G, Zink K. On the neutron radiation field and air activation around a medical electron linac. Radiat Prot Dosimetry. 2017 174(2). doi:10.1093/rpd/ncw120. PMID: 27170731

Kuhnt T, Schreiber A, Pirnasch A, Hautmann MG, Hass P, Sieker FP, Engenhart-Cabillic R, Richter M, Dellas K, Dunst J. Hyperfractionated accelerated radiation therapy plus cetuximab plus cisplatin chemotherapy in locally advanced inoperable squamous cell carcinoma of the head and neck : Final 5‑year results of a phase II study. Strahlenther Onkol. 2017 Sep;193(9):733-741. doi:10.1007/s00066-017-1145-6. PMID: 28500491.

Kriz J, Baues C, Engenhart-Cabillic R, Haverkamp U, Herfarth K, Lukas P. New quality assurance program integrating "modern radiotherapy" within the German Hodgkin Study Group. Strahlenther Onkol. 2017 Feb;193(2):100-108. doi:10.1007/s00066-016-1048-y. PMID: 27678010.

Kriz J, Baues C, Engenhart-Cabillic R, Haverkamp U, Herfart K, Lukas P, Plütschow A, Schmidberger H, Marnitz-Schulze S, Fuchs M, Engert A, Eich HAT. Quality control of involved field radiotherapy in the HD 13 and HD 14 trials: Report of the radiotherapy panel of the German Hodgkin Study Group (GHSG). Strahlenther Onkol. 2017 Feb;193(2):109-115. doi:10.1007/s00066-016-1036-2. PMID: 27596217.

Printz Ringbæk T, Simeonov Y, Witt M, Engenhart-Cabillic R, Kraft G, Zink K, Weber U. Modulation power of porous materials and usage as ripple filter in particle therapy. Phys Med Biol. 2017 62(7):2892–2909. doi:10.1088/1361-6560/aa5c28. PMID: 28140381.

Rieber J, Abbassi-Senger N, Adebahr S, Andratschke N, Blanck O, Duma M, Eble MJ, Ernst I, Flentje M, Gerum S, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl H, Klass ND, Krempien R, Lohaus F, Lohr F, Petersen C, Schrade E, Streblow J, Uhlmann L, Wittig A, Sterzing F, Guckenberger M. Influence of Institutional Experience and Technological Advances on Outcome of Stereotactic Body Radiation Therapy for Oligometastatic Lung Disease. Int J Radiat Oncol Biol Phys. 2017 Jul 1;98(3):511-520 doi:10.1016/j.ijrobp.2016.09.026. PMID: 27843031.

Schröder C, Engenhart-Cabillic R, Vorwerk H, Schmidt M, Huhnt W, Blank E, Sidow D, Buchali A. Changes in pulmonary function and influencing factors after high-dose intrathoracic radio(chemo)therapy. Strahlenther Onkol. 2017 193(2):125–131. doi:10.1007/s00066-016-1067-8. PMID: 27783103

Schröder C, Engenhart-Cabillic R, Vorwerk H, Schmidt M, Huhnt W, Blank E, Sidow D, Buchali A. Patient’s quality of life after high-dose radiation therapy for thoracic carcinomas: Changes over time and influence on clinical outcome. Strahlenther Onkol. 2017 193(2):132–140. doi:10.1007/s00066-016-1068-7. PMID: 27787567.

Simeonov Y, Weber U, Penchev P, Printz Ringbæk T, Schuy Ch, Brons S, Engenhart-Cabillic R, Bliedtner J, Zink K. 3D range-modulator for scanned particle therapy: development, Monte Carlo simulations and experimental evaluation. Phys. Med. Biol. 2017 62: 7075-7096. doi:10.1088/1361-6560/aa81f4. PMID: 28741595.

Tanadini-Lang S, Rieber J, Filippi AR, Fode MM, Streblow J, Adebahr S, Andratschke N, Blanck O, Boda-Heggemann J, Duma M, …, Wittig A, u. a. Nomogram based overall survival prediction in stereotactic body radiotherapy for oligo-metastatic lung disease. Radiother Oncol. 2017 123(2):182–188. doi:10.1016/j.radonc.2017.01.003. PMID: 28169042.

Toke Printz Ringbæk, Yuri Simeonov, Matthias Witt, Rita Engenhart-Cabillic, Gerhard Kraft, Klemens Zink, Uli Weber. Modulation power of porous materials and usage as ripple filter in particle therapy. Phys Med Biol. 2017 Apr 7;62(7):2892-2909. doi:10.1088/1361-6560/aa5c28. PMID: 28140381.

von Voigts-Rhetz P, Vorwerk H, Zink K. On the Perturbation Correction Factor pcav of the Markus Parallel-Plate Ion Chamber in Clinical Electron Beams. Int. J. Med. Phys. Clin.Eng. Rad. Oncol. 2017 6: 150-161.

Wagner DM, Hüttenrauch P, Anton M, von Voigts-Rhetz P, Zink K, Wolff HA. Feasibility study of entrance and exit dose measurements at the contra lateral breast with alanine/electron spin resonance dosimetry in volumetric modulated radiotherapy of breast cancer. Phys Med Biol. 2017 Jul 7;6e2(13):5462-5472. doi:10.1088/1361-6560/aa6ee2. PMID: 28436921.

Ziemann F, Seltzsam S, Dreffke K, Preising S, Arenz A, Subtil FSB, Rieckmann T, Engenhart-Cabillic R, Dikomey E, Wittig A. Roscovitine strongly enhances the effect of olaparib on radiosensitivity for HPV neg. but not for HPV pos. HNSCC cell lines. Oncotarget. 2017 8(62):105170–105183. doi:10.18632/oncotarget.22005. PMID: 29285242.

Publikationen 2016

Eberle F, Saulich MF, Leinberger FH, Seeger W, Engenhart-Cabillic R, Dikomey E, Hänze J, Hattar K, Subtil FS. Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation. Radiother Oncol. 2016 Jun;119(3):537-43. doi:10.1016/j.radonc.2016.04.036. PMID: 27178146.

Eekers DB, Roelofs E, Jelen U, Kirk M, Granzier M, Ammazzalorso F, Ahn PH, Janssens GO, Hoebers FJ, Friedmann T, Solberg T, Walsh S, Troost EG, Kaanders JH, Lambin P. Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial. Radiother Oncol. 2016 Dec;121(3):387-394. doi:10.1016/j.radonc.2016.08.020. PMID: 27639891.

Horst F, Schuy Ch, Weber U, Brinkmann K-T, Zink K. Measurement of charge- and mass-changing cross sections for 4He + 12C collisions in the energy range 80 - 220 MeV/u for applications in ion beam therapy. Phys. Rev. C 2016 96: 024624-1 - 024624-11.

von Voigts-Rhetz P, Anton M, Vorwerk H, Zink K. Perturbation correction for alanine dosimeters in different phantom materials in high-energy photon beams. Phys Med Biol. 2016 Feb 7;61(3):N70-9. doi:10.1088/0031-9155/61/3/N70. PMID: 26758810.

Ringbæk TP, Weber U, Santiago A, Simeonov Y, Fritz P, Krämer M, Wittig A, Bassler N, Engenhart-Cabillic R, Zink K. Dosimetric comparisons of carbon ion treatment plans for 1D and 2D ripple filters with variable thicknesses. Phys Med Biol. 2016 Jun 7;61(11):4327-41. doi:10.1088/0031-9155/61/11/4327. PMID: 27203127

Santiago A, Barczyk S, Jelen U, Engenhart-Cabillic R, Wittig A. Challenges in radiobiological modeling: Can we decide between LQ and LQ-L models based on reviewed clinical NSCLC treatment outcome data? Radiat Oncol. 2016 May 6;11(1):67. doi:10.1186/s13014-016-0643-5. PMID: 27154064.

Schröder C, Engenhart-Cabillic R, Vorwerk H, Schmidt M, Huhnt W, Blank E, Sidow D, Buchali A. A lot to a little or a little to a lot-which dose-volume relationship ensures the best clinical outcome in the high dose radiation therapy of thoracic tumors? A prospective approach. J Thorac Dis. 2016 Aug;8(8):2053-60. doi:10.21037/jtd.2016.07.92. PMID: 27621859

Teymoortash A, Pfestroff A, Wittig A, Franke N, Hoch S, Harnisch S, Schade-Brittinger C, Hoeffken H, Engenhart-Cabillic R, Brugger M, Strauch K. Safety and Efficacy of Botulinum Toxin to Preserve Gland Function after Radiotherapy in Patients with Head and Neck Cancer: A Prospective, Randomized, Placebo-Controlled, Double-Blinded Phase I Clinical Trial. PLoS One. 2016 Mar 18;11(3):e0151316. doi:10.1371/journal.pone.0151316. PMID: 26991494.

Ziemann F; Seltzsam S, Dreffke K, Preising S, Arenz A, Subtil FSB, Rieckmann T, Engenhart-Cabillic R, Dikomey E, Wittig A. Roscovitine strongly enhances the effect of olaparib on radiosensitivity for HPV neg. but not for HPV pos. HNSCC cell lines. Oncotarget 2016 8(62):105170-105183. doi:10.18632/oncotarget.22005. PMID: 29285242.

Publikationen 2015

Ammazzalorso F, Jelen U, Engenhart-Cabillic R, Schlegel W. Dosimetric robustness against setup errors in charged particle radiotherapy of skull base tumors. Radiat Oncol. 2014 Dec 5;9:279. doi:10.1186/s13014-014-0279-2. PMID: 25477197.

Göpfert F, Schmidt R, Wulff J, Zink K. Effect of ROI filtering in 3D cone-beam rotational angiography on organ dose and effective dose in cerebral investigations. J Appl Clin Med Phys. 2015 Mar 8;16(2):5306. doi:10.1120/jacmp.v16i2.5306. PMID: 26103200.

Horst F, Czarnecki D, Zink K. The influence of neutron contamination on dosimetry in external photon beam radiotherapy. Med Phys. 2015 Nov;42(11):6529-36. doi:10.1118/1.4933246. PMID: 26520743.

Horst F, Fehrenbacher G, Radon T, Kozlova E, Rosmej O, Czarnezki D, Schrenk O, Breckow J, Zink K. A TLD-based ten channel system for the spectrometry of bremsstrahlung generated by laser-matter interaction. Nuc. Inst. Meth. Phys. A 782 (2015): 69-76.

Iancu G, Kraemer M, Zink K., Durante M, Weber U. Implementation of an efficient Monte Carlo algorithm in TRiP: Physical dose calculation. Int J Part Ther 2 (2015):415-425.

Kriz J, Reinartz G, Dietlein M, Kobe C, Kuhnert G, Haverkamp H, Haverkamp U, Engenhart-Cabillic R, Herfarth K, Lukas P, Schmidberger H, Staar S, Hegerfeld K, Baues C, Engert A, Eich HAT. Relapse Analysis of Irradiated Patients Within the HD15 Trial of the German Hodgkin Study Group. Int J Radiat Oncol Biol Phys. 2015 May 1;92(1):46-53. doi:10.1016/j.ijrobp.2015.01.048. PMID: 25863753.

Olbert PJ, Kesch C, Henrici M, Subtil FS, Honacker A, Hegele A, Hofmann R, Hänze J. TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells. Urol Oncol. 2015 Mar;33(3):110.e19-27. doi:10.1016/j.urolonc.2014.09.016. PMID: 25499923.

Ringbæk TP, Brons S, Naumann J, Ackermann B, Horn J, Latzel H, Scheloske S, Galonska M, Bassler N, Zink K, Weber U. Fluence inhomogeneities due to a ripple filter induced Moiré effect. Phys Med Biol. 2015 Feb 7;60(3):N59-69. doi:10.1088/0031-9155/60/3/N59. PMID: 25590354.

Santiago A, Fritz P, Mühlnickel W, Engenhart-Cabillic R, Wittig A. Changes in the radiological depth correlate with dosimetric deterioration in particle therapy for stage I NSCLC patients under high frequency jet ventilation. Acta Oncol. 2015;54(9):1631-7. doi:10.3109/0284186X.2015.1067716. PMID: 26228661.

Schmidt R, Wulff J, Zink K. GMctdospp: Description and validation of a CT dose calculation system. Med Phys. 2015 Jul;42(7):4260-70. doi:10.1118/1.4922391. PMID: 26133624

Wiegel T, Bartkowiak D, Bottke D, Thamm R, Hinke A, Stöckle M, Rübe C, Semjonow, A, Wirth M, Störkel S, Golz R, Engenhart-Cabillic R, Hofmann R, Feldmann HJ, Kälble T, Siegmann A, Hinkelbein W, Steiner U, Miller K. Prostate-specific antigen persistence after radical prostatectomy as a predictive factor of clinical relapse-free survival and overall survival: 10-year data of the ARO 96-02 trial. Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):288-94. doi:10.1016/j.ijrobp.2014.09.039. PMID: 25445556.

Witt M, Weber U, Kellner D, Engenhart-Cabillic R, Zink K. Optimization of the stopping-power-ratio to Hounsfield-value calibration curve in proton and heavy ion therapy. Z Med Phys. 2015 Sep;25(3):251-63. doi:10.1016/j.zemedi.2014.11.001. PMID: 25497583.

Ziemann F, Arenz A, Preising S, Wittekindt C, Klussmann JP, Engenhart-Cabillic R, Wittig A. Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation +/- Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis. Am J Cancer Res. 2015 Feb 15;5(3):1017-31. PMID: 26045983.

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